AF035: Peroxidase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyze a number of oxidative reactions. Haem peroxidases are classified into two families: this family contains the enzymes from bacteria, fungi, and plants [1], while animal haem peroxidases constitute their own family (Pfam:PF03098).

Allergens from this family

Plant peroxidases are secreted glycoproteins. IgE binding plant peroxidases were identified in bell pepper, tomato, and wheat [2]. These proteins bind IgE probably exclusively through their N-glycan moieties. Horseradish peroxidase (HRP) has been widely used as a model protein for studying IgE binding properties of plant N-glycans [3]. Mus a 6, an ascorbate peroxidase from banana, was shown to bind IgE also in its recombinant, non-glycosylated form produced in Escherichia coli.



  1. Passardi F, Bakalovic N, Teixeira FK, Margis-Pinheiro M, Penel C, Dunand C:
    Prokaryotic origins of the non-animal peroxidase superfamily and organelle-mediated transmission to eukaryotes.
    Genomics 2007, 89, 567-79. [PubMed] [Full Text]
  2. Yamashita H, Nanba Y, Onishi M, Kimoto M, Hiemori M, Tsuji H:
    Identification of a wheat allergen, Tri a Bd 36K, as a peroxidase.
    Biosci Biotechnol Biochem 2002, 66, 2487-90. [PubMed]
  3. Malandain H:
    IgE-reactive carbohydrate epitopes--classification, cross-reactivity, and clinical impact (2nd part).
    Eur Ann Allergy Clin Immunol 2005, 37, 247-56. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00141 Peroxidase CL0617 Heme-dependent peroxidases superfamily

Links to Wikipedia


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