Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyze a number of oxidative reactions. Haem peroxidases are classified into two families: this family contains the enzymes from bacteria, fungi, and plants , while animal haem peroxidases constitute their own family (Pfam:PF03098).
Plant peroxidases are secreted glycoproteins. IgE binding plant peroxidases were identified in bell pepper, tomato, and wheat . These proteins bind IgE probably exclusively through their N-glycan moieties. Horseradish peroxidase (HRP) has been widely used as a model protein for studying IgE binding properties of plant N-glycans . Mus a 6, an ascorbate peroxidase from banana, was shown to bind IgE also in its recombinant, non-glycosylated form produced in Escherichia coli.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00141||Peroxidase||CL0617||Heme-dependent peroxidases superfamily|
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