The metallo-phosphoesterase motif is found in a large number of enzymes including serine/threonine phosphatases, DNA polymerase, exonucleases, nucleotidases, sphingomyelin phosphodiesterases, and 2'-3' cAMP phosphodiesterases .
Aed a 1, an apyrase (adenosine diphosphatase) from the mosquito Aedes aegypti was identified as an allergen recognized by 43% of mosquito-allergic patients in skin tests .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00149||Calcineurin-like phosphoesterase||CL0163||Calcineurin-like phosphoesterase superfamily|
|PF02872||5'-nucleotidase, C-terminal domain||-|
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