AF036: Calcineurin-like phosphoesterase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The metallo-phosphoesterase motif is found in a large number of enzymes including serine/threonine phosphatases, DNA polymerase, exonucleases, nucleotidases, sphingomyelin phosphodiesterases, and 2'-3' cAMP phosphodiesterases [1].

Allergens from this family

Aed a 1, an apyrase (adenosine diphosphatase) from the mosquito Aedes aegypti was identified as an allergen recognized by 43% of mosquito-allergic patients in skin tests [2].



  1. Aravind L, Koonin EV:
    Phosphoesterase domains associated with DNA polymerases of diverse origins.
    Nucleic Acids Res 1998, 26, 3746-52. [PubMed]
  2. Simons FE, Peng Z:
    Mosquito allergy: recombinant mosquito salivary antigens for new diagnostic tests.
    Int Arch Allergy Immunol 2001, 124, 403-5. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00149 Calcineurin-like phosphoesterase CL0163 Calcineurin-like phosphoesterase superfamily
PF02872 5'-nucleotidase, C-terminal domain -

Links to Wikipedia


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