AF038: Cyclophilin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline is stabilised in the cis conformation. Mammalian cyclophilin A is a major cellular target for the immunosuppressive drug cyclosporin A. Other roles for cyclophilins may include chaperone and cell signaling functions. [1].

Allergens from this family

Allergenic members of the cyclophilin family were found in fungi and plants. Fungal allergens include Aps f 11 and Asp f 27 from Aspergillus fumigatus and Mala s 6 from Malassezia sympodialis [2]. The minor birch pollen allergen Bet v 7 is a cyclophilin [3]. An IgE binding cyclophilin from carrot is not cross-reactive with the birch pollen homologue [4].



  1. Wang P, Heitman J:
    The cyclophilins.
    Genome Biol 2005, 6, 226. [PubMed] [Full Text]
  2. Glaser AG, Limacher A, Fluckiger S, Scheynius A, Scapozza L, Crameri R:
    Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family.
    Biochem J 2006, 396, 41-9. [PubMed] [Full Text]
  3. Cadot P, Nelles L, Srahna M, Dilissen E, Ceuppens JL:
    Cloning and expression of the cyclophilin Bet v 7, and analysis of immunological cross-reactivity among the cyclophilin A family.
    Mol Immunol 2006, 43, 226-35. [PubMed] [Full Text]
  4. Fujita C, Moriyama T, Ogawa T:
    Identification of cyclophilin as an IgE-binding protein from carrots.
    Int Arch Allergy Immunol 2001, 125, 44-50. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD CL0475 Cyclophilin-like superfamily

Links to Wikipedia


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