Cyclophilins have been found in all organisms studied so far and catalyze peptidyl-prolyl isomerisation during which the peptide bond preceding proline is stabilised in the cis conformation. Mammalian cyclophilin A is a major cellular target for the immunosuppressive drug cyclosporin A. Other roles for cyclophilins may include chaperone and cell signaling functions. [1].
Allergenic members of the cyclophilin family were found in fungi and plants. Fungal allergens include Aps f 11 and Asp f 27 from Aspergillus fumigatus and Mala s 6 from Malassezia sympodialis [2]. The minor birch pollen allergen Bet v 7 is a cyclophilin [3]. An IgE binding cyclophilin from carrot is not cross-reactive with the birch pollen homologue [4].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00160 | Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD | CL0475 | Cyclophilin-like superfamily |
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