AF042: Heat shock protein Hsp90

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Prokaryotes and eukaryotes respond to heat shock and other forms of environmental stress by inducing synthesis of heat-shock proteins (Hsp). The 90 kDa Hsp90 is found in bacteria and eukaryotes. It is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation [1]. Hsp90 contains four domains and forms homodimers where the contact sites are localized within the C-terminus in the open conformation of the dimer, while the N-termini come into contact only in the closed conformation.

Allergens from this family

Asp f 12 is an IgE-binding Hsp90 from the mould Aspergillus fumigatus [2].



  1. Csermely P, Schnaider T, Soti C, Prohaszka Z, Nardai G:
    The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review.
    Pharmacol Ther 1998, 79, 129-68. [PubMed]
  2. Kumar A, Reddy LV, Sochanik A, Kurup VP:
    Isolation and characterization of a recombinant heat shock protein of Aspergillus fumigatus.
    J Allergy Clin Immunol 1993, 91, 1024-30. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00183 Hsp90 protein -

Links to Wikipedia


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