AF046: Kunitz soybean trypsin inhibitor family
The Kunitz-type soybean trypsin inhibitor (STI) family consists mainly of proteinase inhibitors from legume seeds. The STIs belong to the β-trefoil superfamily that also contains the interleukin-1 proteins, heparin binding growth factors and histactophilin, all of which have very similar structures, but share no sequence similarity with the STI family .
Allergens from this family
The Kunitz trypsin inhibitor from soybean was identified as a minor allergen . In potato, three protease inhibitors bound IgE from about half of the sera of atopic children .
beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors.
J Mol Biol 1992, 223, 531-43. [PubMed]
Identification of peanut agglutinin and soybean trypsin inhibitor as minor legume allergens.
Int Arch Allergy Immunol 1994, 105, 143-9. [PubMed]
Identification of four novel potato (Solanum tuberosum) allergens belonging to the family of soybean trypsin inhibitors.
Allergy 2001, 56, 619-26. [PubMed]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Trypsin and protease inhibitor
Links to Wikipedia
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