AF049: ATP:guanido phosphotransferase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

ATP:guanido phosphotransferases are a family of structurally and functionally related enzymes that reversibly catalyze the transfer of phosphate between ATP and various phosphogens. The substrate binding site is located in the cleft between N and C-terminal domains [1].

Allergens from this family

Allergenic members of this family are arginine kinases. These are minor allergens from crustaceans, mites, and insects [2, 3].



  1. Strong SJ, Ellington WR:
    Isolation and sequence analysis of the gene for arginine kinase from the chelicerate arthropod, Limulus polyphemus: insights into catalytically important residues.
    Biochim Biophys Acta 1995, 1246, 197-200. [PubMed]
  2. Pedrosa M, Boyano-Martinez T, Garcia-Ara C, Quirce S:
    Shellfish Allergy: a Comprehensive Review.
    Clin Rev Allergy Immunol 2015, 49, 203-16. [PubMed] [Full Text]
  3. Binder M, Mahler V, Hayek B, Sperr WR, Scholler M, Prozell S, Wiedermann G, Valent P, Valenta R, Duchene M:
    Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen.
    J Immunol 2001, 167, 5470-7. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain CL0286 gamma-glutamylcysteine synthetase/glutamine synthetase clan
PF02807 ATP:guanido phosphotransferase, N-terminal domain -

Links to Wikipedia


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