AF051: Profilin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Profilins are cytosolic proteins of 12-15 kDa in size, which are found in all eukaryotic cells. Profilins bind to monomeric actin (G actin) and a plethora of other proteins, thus regulating the dynamics of actin polymerization during processes such as cell movement, cytokinesis, and signaling [1].

Allergens from this family

Profilins from higher plants constitute a family of highly conserved proteins showing sequence identities of at least 75% even between members from distantly related organisms. Profilins from pollen, plant foods, and Hevea latex are minor albeit highly cross-reactive allergens eliciting IgE responses in 10-20% of pollen-allergic patients [2]. Since profilin-specific IgE usually cross-reacts with homologues from virtually every plant source, sensitization to these allergens has been considered a risk factor for allergic reactions to multiple pollen sources [3] and for pollen-associated food allergy [4].



  1. Witke W:
    The role of profilin complexes in cell motility and other cellular processes.
    Trends Cell Biol 2004, 14, 461-9. [PubMed] [Full Text]
  2. Valenta R, Duchene M, Ebner C, Valent P, Sillaber C, Deviller P, Ferreira F, Tejkl M, Edelmann H, Kraft D, et al.:
    Profilins constitute a novel family of functional plant pan-allergens.
    J Exp Med 1992, 175, 377-85. [PubMed]
  3. Mari A:
    Multiple pollen sensitization: a molecular approach to the diagnosis.
    Int Arch Allergy Immunol 2001, 125, 57-65. [PubMed] [Full Text]
  4. Asero R, Mistrello G, Roncarolo D, Amato S, Zanoni D, Barocci F, Caldironi G:
    Detection of clinical markers of sensitization to profilin in patients allergic to plant-derived foods.
    J Allergy Clin Immunol 2003, 112, 427-32. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00235 Profilin CL0431 Profilin-like superfamily

Links to Wikipedia


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