AF054: Tropomyosin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Tropomyosins are present in muscle and non-muscle cells. In striated muscle, they mediate the interactions between the troponin complex and actin so as to regulate muscle contraction [1]. The role of tropomyosin in smooth muscle and non-muscle tissues is not clear [2]. Tropomyosin is an α-helical protein that forms a coiled-coil structure of two parallel helices containing two sets of seven alternating actin binding sites.

Allergens from this family

Tropomyosins were identified as minor inhalative allergens in arthropods (mites, cockroaches) and as major food allergens in crustaceans, mollusks, and the fish parasite Anisakis simplex [3]. Vertebrate tropomyosins seem to be non-allergenic. Due to their repetitive coiled-coil structures, tropomyosins retain their IgE binding ability even after prolonged heating or partial digestion. Tropomyosin sequences are highly conserved, which explains the frequent cross-sensitization among distantly related allergen sources.



  1. Brown JH, Cohen C:
    Regulation of muscle contraction by tropomyosin and troponin: how structure illuminates function.
    Adv Protein Chem 2005, 71, 121-59. [PubMed] [Full Text]
  2. Gunning PW, Schevzov G, Kee AJ, Hardeman EC:
    Tropomyosin isoforms: divining rods for actin cytoskeleton function.
    Trends Cell Biol 2005, 15, 333-41. [PubMed] [Full Text]
  3. Jeong KY, Hong CS, Yong TS:
    Allergenic tropomyosins and their cross-reactivities.
    Protein Pept Lett 2006, 13, 835-45. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00261 Tropomyosin CL0452 Tropomyosin-like superfamily

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .