AF055: Calreticulin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Calreticulin is a high-capacity calcium-binding protein which is present in most tissues and located at the periphery of the endoplasmic (ER) and the sarcoplamic reticulum (SR) membranes. It plays a role in the storage of calcium in the lumen of the ER and SR and is also an important molecular chaperone involved in quality control within secretory pathways [1]. This family also includes calnexin and camlegin.

Allergens from this family

The Penicillium chrysogenum allergen Pen ch 31 is a calreticulin.



  1. Gelebart P, Opas M, Michalak M:
    Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum.
    Int J Biochem Cell Biol 2005, 37, 260-6. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00262 Calreticulin family -

Links to Wikipedia


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