AF057: Polygalacturonase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Glycoside hydrolase family 28 comprises enzymes with polygalacturonase, exo-polygalacturonase, or rhamnogalacturonase activity. Polygalacturonase (pectinase) catalyzes the random hydrolysis of 1,4-α-D-galactosiduronic linkages in pectate and other galacturonans. In fruits, polygalacturonase plays an important role in cell wall metabolism during ripening [1]. In plant pathogens, polygalacturonase is involved in maceration and soft-rotting of plant tissue.

Allergens from this family

Polygalacturonases are major pollen allergens in Cupressaceae trees (group 2 allergens) [2]. In addition, they were identified in grass pollen (group 13) [3] and in plane tree pollen (Pla a 2). Polygalacturonases contain N-linked glycans, which take part in IgE binding [4].



  1. Willats WG, McCartney L, Mackie W, Knox JP:
    Pectin: cell biology and prospects for functional analysis.
    Plant Mol Biol 2001, 47, 9-27. [PubMed]
  2. Di Felice G, Barletta B, Tinghino R, Pini C:
    Cupressaceae pollinosis: identification, purification and cloning of relevant allergens.
    Int Arch Allergy Immunol 2001, 125, 280-9. [PubMed] [Full Text]
  3. Andersson K, Lidholm J:
    Characteristics and immunobiology of grass pollen allergens.
    Int Arch Allergy Immunol 2003, 130, 87-107. [PubMed] [Full Text]
  4. Wicklein D, Lindner B, Moll H, Kolarich D, Altmann F, Becker WM, Petersen A:
    Carbohydrate moieties can induce mediator release: a detailed characterization of two major timothy grass pollen allergens.
    Biol Chem 2004, 385, 397-407. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00295 Glycosyl hydrolases family 28 CL0268 Pectate lyase-like beta helix

Additional Pfam domains found in some family members:

Pfam domain Pfam clan
PF17181 Epidermal patterning factor proteins -

Links to Wikipedia


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