Plant defensins (also called γ-thionins) consist of a globular domain of 45-50 amino acids in length containing four conserved disulfide bonds. Some family members also contain a C-terminal unstructured, hydroxyproline-rich domain. The structure of the N-terminal domain differs from that of plant α- and β-thionins, but is similar to the structures of scorpion toxins and insect defensins. The peanut allergens Ara h 12 and Ara h 13 also belong to this family .
This family contains the major mugwort pollen allergen, Art v 1  and its ragweed homologue, Amb a 4 . The C-terminal domain contains many hydroxyproline residues that are modified by unusual O-glycans, which take part in IgE binding .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00304||Gamma-thionin family||CL0054||Scorpion toxin-like knottin superfamily|
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