AF060: Thaumatin-like protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The family of thaumatin-like proteins (TLPs), also designated pathogenesis-related proteins PR-5, comprises proteins with diverse functions. Most family members were found in plants, but TLPs were also identified in fungi, C. elegans, mites, and insects [1]. Their synthesis in plants is induced in response to biotic or abiotic stress, but is also developmentally regulated particularly in fruits during ripening [2]. The majority of TLPs has a molecular mass of about 20 kDa, mainly consists of anti-parallel β-sheets and is stabilized by eight disulfide bonds [3]. There are acidic, basic and neutral TLPs. The basic TLPs tend to be in vacuoles or other vesicles, while the acidic forms are more likely secreted into the extracellular spaces. TLPs are stable at low pH and resistant to heat treatment and proteolytic degradation [4].

Allergens from this family

TLPs have been characterized as minor allergens in several fruits such as apple (Mal d 2), cherry (Pru av 2), bell paper (Cup a 1), kiwifruit (Act d 2), orange, and grape as well as in pollen of tress from the family Cupressaceae such as mountain cedar (Jun a 3), and cypress (Cup a 3) [5]. Fruit TLPs retain their IgE binding ability after heating and gastrointestinal digestion [4].



  1. Brandazza A, Angeli S, Tegoni M, Cambillau C, Pelosi P:
    Plant stress proteins of the thaumatin-like family discovered in animals.
    FEBS Lett 2004, 572, 3-7. [PubMed] [Full Text]
  2. Fils-Lycaon BR, Wiersma PA, Eastwell KC, Sautiere P:
    A cherry protein and its gene, abundantly expressed in ripening fruit, have been identified as thaumatin-like.
    Plant Physiol 1996, 111, 269-73. [PubMed]
  3. Leone P, Menu-Bouaouiche L, Peumans WJ, Payan F, Barre A, Roussel A, Van Damme EJ, Rouge P:
    Resolution of the structure of the allergenic and antifungal banana fruit thaumatin-like protein at 1.7-A.
    Biochimie 2006, 88, 45-52. [PubMed] [Full Text]
  4. Bublin M, Radauer C, Knulst A, Wagner S, Scheiner O, Mackie AR, Mills EN, Breiteneder H:
    Effects of gastrointestinal digestion and heating on the allergenicity of the kiwi allergens Act d 1, actinidin, and Act d 2, a thaumatin-like protein.
    Mol Nutr Food Res 2008, 52, 1130-9. [PubMed] [Full Text]
  5. Breiteneder H:
    Thaumatin-like proteins -- a new family of pollen and fruit allergens.
    Allergy 2004, 59, 479-81. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00314 Thaumatin family -

Links to Wikipedia


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