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AF061: Prolyl oligopeptidase family
Biochemical properties
The members of this family of serine proteases belong to MEROPS family S9. It contains several subfamilies:
- Prolyl endopeptidases cleave peptide bonds on the C-terminal side of prolyl residues. They were identified in mammals and bacteria.
- Dipeptidyl peptidases IV remove N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
- Escherichia coli protease II (oligopeptidase B), which cleaves peptide bonds on the C-terminal side of lysyl and argininyl residues.
- Yeast vacuolar dipeptidyl aminopeptidases A and B.
- Acylamino acid-releasing enzymes (acyl peptide hydrolases), which catalyses the hydrolysis of the amino-terminal peptide bond of an N-acetylated protein.
Allergens from this family
All allergens belonging to this family are dipeptidyl peptidases. They were identified in several species of the dermatophytic fungus Trichophyton [1] and in bee and wasp venoms [2].
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References
- Woodfolk JA, Wheatley LM, Piyasena RV, Benjamin DC, Platts-Mills TA:
Trichophyton antigens associated with IgE antibodies and delayed type hypersensitivity. Sequence homology to two families of serine proteinases.
J Biol Chem 1998, 273, 29489-96. [PubMed]
- Blank S, Seismann H, Bockisch B, Braren I, Cifuentes L, McIntyre M, Ruhl D, Ring J, Bredehorst R, Ollert MW, Grunwald T, Spillner E:
Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3.
J Immunol 2010, 184, 5403-13. [PubMed] [Full Text]
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Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain |
Pfam clan |
|
PF00326
|
Prolyl oligopeptidase family
|
CL0028
|
Alpha/Beta hydrolase fold
|
|
PF00930
|
Dipeptidyl peptidase IV (DPP IV) N-terminal region
|
CL0186
|
Beta propeller clan
|
Additional Pfam domains found in some family members:
| Pfam domain |
Pfam clan |
|
PF07676
|
WD40-like Beta Propeller Repeat
|
CL0186
|
Beta propeller clan
|
Links to Wikipedia
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