AF061: Prolyl oligopeptidase family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The members of this family of serine proteases belong to MEROPS family S9. It contains several subfamilies:

Allergens from this family

All allergens belonging to this family are dipeptidyl peptidases. They were identified in several species of the dermatophytic fungus Trichophyton [1] and in bee and wasp venoms [2].



  1. Woodfolk JA, Wheatley LM, Piyasena RV, Benjamin DC, Platts-Mills TA:
    Trichophyton antigens associated with IgE antibodies and delayed type hypersensitivity. Sequence homology to two families of serine proteinases.
    J Biol Chem 1998, 273, 29489-96. [PubMed]
  2. Blank S, Seismann H, Bockisch B, Braren I, Cifuentes L, McIntyre M, Ruhl D, Ring J, Bredehorst R, Ollert MW, Grunwald T, Spillner E:
    Identification, recombinant expression, and characterization of the 100 kDa high molecular weight Hymenoptera venom allergens Api m 5 and Ves v 3.
    J Immunol 2010, 184, 5403-13. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00326 Prolyl oligopeptidase family CL0028 Alpha/Beta hydrolase fold
PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region CL0186 Beta propeller clan

Additional Pfam domains found in some family members:

Pfam domain Pfam clan
PF07676 WD40-like Beta Propeller Repeat CL0186 Beta propeller clan

Links to Wikipedia


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