The histidine phosphatase superfamily derives its name from a conserved His residue in the catalytic center that is transiently phosphorylated during the catalytic cycle . The superfamily is divided into two main branches. The smaller branch 2 contains predominantly eukaryotic proteins. Their functions include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatases.
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00328||Histidine phosphatase superfamily (branch 2)||CL0071||Histidine phosphatase superfamily|
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