AF062: Histidine phosphatase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The histidine phosphatase superfamily derives its name from a conserved His residue in the catalytic center that is transiently phosphorylated during the catalytic cycle [1]. The superfamily is divided into two main branches. The smaller branch 2 contains predominantly eukaryotic proteins. Their functions include phytase, glucose-1-phosphatase and multiple inositol polyphosphate phosphatases.

Allergens from this family

The major honeybee allergen Ap m 3 and Asp n 25, a phytase from Aspergillus niger, belong to this family [2, 3].



  1. Rigden DJ:
    The histidine phosphatase superfamily: structure and function.
    Biochem J 2008, 409, 333-48. [PubMed] [Full Text]
  2. Grunwald T, Bockisch B, Spillner E, Ring J, Bredehorst R, Ollert MW:
    Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3).
    J Allergy Clin Immunol 2006, 117, 848-54. [PubMed] [Full Text]
  3. Doekes G, Kamminga N, Helwegen L, Heederik D:
    Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger.
    Occup Environ Med 1999, 56, 454-9. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00328 Histidine phosphatase superfamily (branch 2) CL0071 Histidine phosphatase superfamily

Links to Wikipedia


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