AF065: Alpha-beta casein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Caseins can be classified into two families; the first contains the αs1, αs2, and β-caseins, and the second groups the κ-caseins (AllFam:AF085). The α and β-caseins are hydrophobic proteins that are readily precipitated by calcium [1].

Allergens from this family

Allergenic members of this family include major milk allergens from cow, sheep and goat [2].



  1. Holt C, Sawyer L:
    Primary and predicted secondary structures of the caseins in relation to their biological functions.
    Protein Eng 1988, 2, 251-9. [PubMed]
  2. Spuergin P, Walter M, Schiltz E, Deichmann K, Forster J, Mueller H:
    Allergenicity of alpha-caseins from cow, sheep, and goat.
    Allergy 1997, 52, 293-8. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00363 Casein -

Links to Wikipedia


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