AF068: Transferrin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Transferrins are eukaryotic iron-binding glycoproteins that control the level of free iron in biological fluids. The proteins evolved by duplication of a domain, each duplicated domain binding one iron atom. Members of the family include blood serotransferrin (siderophilin), milk lactotransferrin (lactoferrin), egg white ovotransferrin (conalbumin), and membrane-associated melanotransferrin [1].

Allergens from this family

Bovine lactoferrin was identified as an allergen binding IgE from 50% of cow's milk allergic patients' sera [2]. Chicken ovotransferrin (Gal d 3) is a major hen's egg allergen [3].



  1. Lambert LA, Perri H, Halbrooks PJ, Mason AB:
    Evolution of the transferrin family: conservation of residues associated with iron and anion binding.
    Comp Biochem Physiol B Biochem Mol Biol 2005, 142, 129-41. [PubMed] [Full Text]
  2. Natale M, Bisson C, Monti G, Peltran A, Garoffo LP, Valentini S, Fabris C, Bertino E, Coscia A, Conti A:
    Cow's milk allergens identification by two-dimensional immunoblotting and mass spectrometry.
    Mol Nutr Food Res 2004, 48, 363-9. [PubMed] [Full Text]
  3. Aabin B, Poulsen LK, Ebbehoj K, Norgaard A, Frokiaer H, Bindslev-Jensen C, Barkholt V:
    Identification of IgE-binding egg white proteins: comparison of results obtained by different methods.
    Int Arch Allergy Immunol 1996, 109, 50-7. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00405 Transferrin CL0177 Periplasmic binding protein clan

Links to Wikipedia


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