AF070: 60S acidic ribosomal protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The 60S acidic ribosomal proteins are part of the large ribosome subunit and play an important role in the elongation step of protein synthesis. This family includes archaeal L12, and eukaryotic P0, P1 and P2 [1].

Allergens from this family

Members of this family were described as fungal allergens. Alt a 12 from Alternaria alternata and Cla h 12 from Cladosporium herbarum are P1 proteins, while Alt a 5, Cla h 5 and Asp f 8 from Aspergillus fumigatus belong to the P2 family [2]. Autoimmune reactions to human P2 were also described [3].



  1. Tchorzewski M:
    The acidic ribosomal P proteins.
    Int J Biochem Cell Biol 2002, 34, 911-5. [PubMed]
  2. Achatz G, Oberkofler H, Lechenauer E, Simon B, Unger A, Kandler D, Ebner C, Prillinger H, Kraft D, Breitenbach M:
    Molecular cloning of major and minor allergens of Alternaria alternata and Cladosporium herbarum.
    Mol Immunol 1995, 32, 213-27. [PubMed]
  3. Mayer C, Appenzeller U, Seelbach H, Achatz G, Oberkofler H, Breitenbach M, Blaser K, Crameri R:
    Humoral and cell-mediated autoimmune reactions to human acidic ribosomal P2 protein in individuals sensitized to Aspergillus fumigatus P2 protein.
    J Exp Med 1999, 189, 1507-12. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00428 60s Acidic ribosomal protein -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .