AF073: Pectate lyase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Pectate lyases are enzymes from plants and plant pathogens involved in the maceration and soft rotting of plant tissue [1]. They catalyze the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-reducing ends. Pectate lyases are maximally expressed late in pollen development where they are involved in pectin degradation during pollen tube growth.

Allergens from this family

Two groups of allergens belong to this family. The group 1 Cupressaceae pollen allergens are major allergens identified in cedars, junipers, and cypresses [2]. Pectate lyases are also major allergens in weed pollen from the family Asteraceae (Amb a 1 from ragweed and Art v 6 from mugwort). There is only limited cross-reactivity between allergens from different plant families [3].



  1. Marin-Rodriguez MC, Orchard J, Seymour GB:
    Pectate lyases, cell wall degradation and fruit softening.
    J Exp Bot 2002, 53, 2115-9. [PubMed]
  2. Di Felice G, Barletta B, Tinghino R, Pini C:
    Cupressaceae pollinosis: identification, purification and cloning of relevant allergens.
    Int Arch Allergy Immunol 2001, 125, 280-9. [PubMed] [Full Text]
  3. Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F:
    Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern.
    PLoS One 2015, 10, e0120038. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00544 Pectate lyase CL0268 Pectate lyase-like beta helix

Links to Wikipedia


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