Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that binds to the barbed ends of actin filaments, preventing monomer exchange. It can promote nucleation as well as sever existing filaments. Sequence comparisons indicate an evolutionary relationship between gelsolin, villin, fragmin and severin. Six large repeating segments occur in gelsolin and villin, and 3 similar segments in severin and fragmin .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00626||Gelsolin repeat||CL0092||Actin depolymerizing Factor|
|PF02209||Villin headpiece domain||-|
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