AF074: Gelsolin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Gelsolin is a cytoplasmic, calcium-regulated, actin-modulating protein that binds to the barbed ends of actin filaments, preventing monomer exchange. It can promote nucleation as well as sever existing filaments. Sequence comparisons indicate an evolutionary relationship between gelsolin, villin, fragmin and severin. Six large repeating segments occur in gelsolin and villin, and 3 similar segments in severin and fragmin [1].

Allergens from this family

An IgE binding villin was isolated from a tobacco cDNA library [2]. The minor house dust mite allergen Der f 16 is a gelsolin-like protein [3].



  1. Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL, Hayoz D:
    Gelsolin superfamily proteins: key regulators of cellular functions.
    Cell Mol Life Sci 2004, 61, 2614-23. [PubMed] [Full Text]
  2. Mittermann I, Voronin V, Heberle-Bors E, Valenta R:
    Identification of a villin-related tobacco protein as a novel cross-reactive plant allergen.
    FEBS Lett 2005, 579, 3807-13. [PubMed] [Full Text]
  3. Kawamoto S, Suzuki T, Aki T, Katsutani T, Tsuboi S, Shigeta S, Ono K:
    Der f 16: a novel gelsolin-related molecule identified as an allergen from the house dust mite, Dermatophagoides farinae.
    FEBS Lett 2002, 516, 234-8. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00626 Gelsolin repeat CL0092 Actin depolymerizing Factor
PF02209 Villin headpiece domain -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .