AF075: GDSL-hydrolase family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains several esterase and lipase enzymes with a characteristic GDSL motif as part of the active site. They show a diverse range of activities such as lipase, arylesterase, carbohydrate esterase, and phospholipase [1].

Allergens from this family

Hev b 4, a glycoallergen from Hevea brasiliensis latex is a lecithinase [2]. IgE binding to this allergen is directed exclusively to its glycan moieties. A second latex allergen from this protein family, Hev b 13, is also a glycoprotein [3].



  1. Molgaard A, Kauppinen S, Larsen S:
    Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases.
    Structure 2000, 8, 373-83. [PubMed]
  2. Sunderasan E, Bahari A, Arif SA, Zainal Z, Hamilton RG, Yeang HY:
    Molecular cloning and immunoglobulin E reactivity of a natural rubber latex lecithinase homologue, the major allergenic component of Hev b 4.
    Clin Exp Allergy 2005, 35, 1490-5. [PubMed] [Full Text]
  3. Arif SA, Hamilton RG, Yusof F, Chew NP, Loke YH, Nimkar S, Beintema JJ, Yeang HY:
    Isolation and characterization of the early nodule-specific protein homologue (Hev b 13), an allergenic lipolytic esterase from Hevea brasiliensis latex.
    J Biol Chem 2004, 279, 23933-41. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00657 GDSL-like Lipase/Acylhydrolase CL0264 SGNH hydrolase superfamily


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