This family contains several esterase and lipase enzymes with a characteristic GDSL motif as part of the active site. They show a diverse range of activities such as lipase, arylesterase, carbohydrate esterase, and phospholipase .
Hev b 4, a glycoallergen from Hevea brasiliensis latex is a lecithinase . IgE binding to this allergen is directed exclusively to its glycan moieties. A second latex allergen from this protein family, Hev b 13, is also a glycoprotein .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00657||GDSL-like Lipase/Acylhydrolase||CL0264||SGNH hydrolase superfamily|
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