AF077: Chitinase class III and peritrophin-like

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The glycoside hydrolase family 18 family contains enzymes with chitinase (chitinase class III group) or endo-β-N-acetylglucosaminidase activity as well as non-catalytic proteins. The family also includes various glycoproteins from mammals such as cartilage glycoprotein and the oviduct-specific glycoproteins. Some family members from animals also contain a pertrophin-like chitin-binding domain, which is also found in chitin binding proteins without chitinase activity, particularly peritrophic matrix proteins of insects [1]. Class III chitinases from plants have bifunctional activities as chitinases and lysozymes [2].

Allergens from this family

Chitinases from mites (group 15 and 18 mite allergens) are highly glycosylated major allergens [3]. In addition, they are major mite allergens for cats and dogs [4]. Group 18 allergens contain a C-terminal peritrophin domain. Group 12 mite allergens also contain a peritrophin domain, but lack a catalytic domain. Some plant allergens belong to the chitinase class III family. Hevamine (Hev b 14) is a bifunctional chitinase/lysozyme from Hevea brasiliensis and a minor natural rubber latex allergen [5].



  1. Shen Z, Jacobs-Lorena M:
    A type I peritrophic matrix protein from the malaria vector Anopheles gambiae binds to chitin. Cloning, expression, and characterization.
    J Biol Chem 1998, 273, 17665-70. [PubMed]
  2. Beintema JJ, Terwisscha van Scheltinga AC:
    Plant lysozymes.
    EXS 1996, 75, 75-86. [PubMed]
  3. O'Neil SE, Heinrich TK, Hales BJ, Hazell LA, Holt DC, Fischer K, Thomas WR:
    The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus.
    Clin Exp Allergy 2006, 36, 831-9. [PubMed] [Full Text]
  4. McCall C, Hunter S, Stedman K, Weber E, Hillier A, Bozic C, Rivoire B, Olivry T:
    Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs.
    Vet Immunol Immunopathol 2001, 78, 231-47. [PubMed]
  5. Lee MF, Wang NM, Han JL, Lin SJ, Tsai JJ, Chen YH:
    Estimating allergenicity of latex gloves using Hev b 1 and hevamine.
    J Investig Allergol Clin Immunol 2010, 20, 499-505. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00704 Glycosyl hydrolases family 18 CL0058 Tim barrel glycosyl hydrolase superfamily
PF01607 Chitin binding Peritrophin-A domain CL0155 Carbohydrate binding domain 14/19 clan

Links to Wikipedia


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