AF081: GMC oxidoreductase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The glucose-methanol-choline (GMC) oxidoreductases are a family of FAD dependent oxidoreductases includes a variety of enzymes such as choline dehydrogenase, methanol oxidase, and cellobiose dehydrogenase [1]. he N-terminal domain corresponds to the FAD ADP-binding domain, the C-terminal domain is a steroid-biding domain.

Allergens from this family

An allergenic member of this family is Mala s 12 from the skin-colonising yeast Malassezia sympodialis, which is a major allergen for patients with atopic eczema [2].



  1. Cavener DR:
    GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities.
    J Mol Biol 1992, 223, 811-4. [PubMed]
  2. Zargari A, Selander C, Rasool O, Ghanem M, Gadda G, Crameri R, Scheynius A:
    Mala s 12 is a major allergen in patients with atopic eczema and has sequence similarities to the GMC oxidoreductase family.
    Allergy 2007, 62, 695-703. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00732 GMC oxidoreductase CL0063 FAD/NAD(P)-binding Rossmann fold Superfamily
PF05199 GMC oxidoreductase -

Links to Wikipedia


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