AF082: Glyoxalase superfamily

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Glyoxalase I (lactoylglutathione lyase) is an ubiquitous Zn-binding enzyme that catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid. A glyoxalase I-like domain is found in other related proteins including the Bleomycin resistance protein and dioxygenases such as 4-hydroxyphenylpyruvate dioxygenase [1].

Allergens from this family

A 33 kDa rice allergen was identified as a glyoxalase [2].



  1. Armstrong RN:
    Mechanistic diversity in a metalloenzyme superfamily.
    Biochemistry 2000, 39, 13625-32. [PubMed]
  2. Usui Y, Nakase M, Hotta H, Urisu A, Aoki N, Kitajima K, Matsuda T:
    A 33-kDa allergen from rice (Oryza sativa L. Japonica). cDNA cloning, expression, and identification as a novel glyoxalase I.
    J Biol Chem 2001, 276, 11376-81. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CL0104 VOC superfamily

Links to Wikipedia


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