AF086: Staphylococcal/streptococcal toxin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Staphylococcus aureus is a Gram-positive coccus that is the major cause of nosocomial infections due to its multiple antibiotic resistant nature. One of the major virulence exotoxins is toxic shock syndrome toxin (TSST), which is secreted by the organism upon successful invasion. It causes a major inflammatory response in the host via superantigenic properties, and is the causative agent of toxic shock syndrome [1]. Other members of this family are staphylococcal enterotoxins and streptococcal pyrogenic exotoxins.

Allergens from this family

Staphylococcal enterotoxins were described as IgE-binding protein involved in the exacerbation of atopic dermatitis [2].



  1. Krakauer T:
    Immune response to staphylococcal superantigens.
    Immunol Res 1999, 20, 163-73. [PubMed]
  2. Nissen D, Pedersen LJ, Skov PS, Vejlsgaard GL, Poulsen LK, Jarlov JO, Karlsmark T, Nolte H:
    IgE-binding components of staphylococcal enterotoxins in patients with atopic dermatitis.
    Ann Allergy Asthma Immunol 1997, 79, 403-8. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01123 Staphylococcal/Streptococcal toxin, OB-fold domain -
PF02876 Staphylococcal/Streptococcal toxin, beta-grasp domain CL0386 Superantigen toxins, C-terminal domain superfamily

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .