AF087: Ole e 1 family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains extracellular plant pollen glycoproteins of about 145 residues in length that contain six conserved cysteine residues. Their biological function is unknown.

Allergens from this family

The prototypic member of this family is the major olive pollen allergen, Ole e 1. This allergen binds IgE from 90% of olive pollen allergic patients' sera [1]. Homologous allergens were identified in other trees from the family Oleaceae (ash, lilac, privet), from grass pollen (group 11 grass pollen allergens), and from weed pollen (plantain, lamb's quarters). These allergens are glycosylated, and the glycan moieties take part in IgE binding [2]. It was shown that IgE cross-reactivity among Ole e 1-related allergens does not extend beyond plant family borders [3].



  1. Quiralte J, Florido F, Arias de Saavedra JM, Gomez A, Saenz de San Pedro B, Gonzalez E, Rodriguez R:
    Olive allergen-specific IgE responses in patients with Olea europaea pollinosis.
    Allergy 2002, 57 Suppl 71, 47-52. [PubMed]
  2. Batanero E, Crespo JF, Monsalve RI, Martin-Esteban M, Villalba M, Rodriguez R:
    IgE-binding and histamine-release capabilities of the main carbohydrate component isolated from the major allergen of olive tree pollen, Ole e 1.
    J Allergy Clin Immunol 1999, 103, 147-53. [PubMed]
  3. Lombardero M, Obispo T, Calabozo B, Lezaun A, Polo F, Barber D:
    Cross-reactivity between olive and other species. Role of Ole e 1-related proteins.
    Allergy 2002, 57 Suppl 71, 29-34. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01190 Pollen proteins Ole e I like -


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