AF089: Lipid-binding serum glycoprotein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

A number of mammalian lipid-binding serum glycoproteins belong to this family. They include the lipopolysaccharide-binding protein (LBP), the bactericidal permeability-increasing protein (BPI), the cholesteryl ester transfer protein (CETP) the phospholipid transfer protein (PLTP), and the palate, lung and nasal epithelium carcinoma-associated protein (PLUNC). These proteins consist of N- and C-terminal domains, which share a similar two-layer α/β structure, but show little sequence identity to each other [1].

Allergens from this family

The horse dander allergen Equ c 4 (a fragment of which was previously named Equ c 5) is a latherin, a surfactant protein in sweat [2].



  1. Weiss J:
    Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria.
    Biochem Soc Trans 2003, 31, 785-90. [PubMed] [Full Text]
  2. Goubran Botros H, Poncet P, Rabillon J, Fontaine T, Laval JM, David B:
    Biochemical characterization and surfactant properties of horse allergens.
    Eur J Biochem 2001, 268, 3126-36. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01273 LBP / BPI / CETP family, N-terminal domain -

Links to Wikipedia


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