AF092: Lipoprotein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family includes several lipid transport proteins, such as vitellogenin, microsomal triglyceride transfer protein and apolipoprotein B-100. Vitellinogens are the major egg yolk proteins that are a source of nutrients during early development of oviparous vertebrates and invertebrates. Vitellinogen precursors are multi-domain apolipoproteins that are cleaved into distinct yolk proteins. In vertebrates, vitellinogen is composed of an N-terminal signal peptide for export, followed by four regions that are cleaved into the yolk proteins lipovitellin-1, phosvitin, lipovitellin-2, and a von Willebrand factor type D domain (YGP40) [1].

Allergens from this family

The group 14 mite allergens are important high molecular weight allergens [2, 3]. Hen's egg yolk YGP42, Gal d 6, is a minor allergen [4]. Fish vitellogenins were identified as cross-reactive fish roe allergens [5]. Moreover, vitellogenins from bee and wasp venoms were identified as minor allergens [6].



  1. Finn RN:
    Vertebrate yolk complexes and the functional implications of phosvitins and other subdomains in vitellogenins.
    Biol Reprod 2007, 76, 926-35. [PubMed] [Full Text]
  2. Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM:
    Characterization and immunobiology of house dust mite allergens.
    Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed] [Full Text]
  3. Epton MJ, Dilworth RJ, Smith W, Hart BJ, Thomas WR:
    High-molecular-weight allergens of the house dust mite: an apolipophorin-like cDNA has sequence identity with the major M-177 allergen and the IgE-binding peptide fragments Mag1 and Mag3.
    Int Arch Allergy Immunol 1999, 120, 185-91. [PubMed] [Full Text]
  4. Amo A, Rodriguez-Perez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML:
    Gal d 6 is the second allergen characterized from egg yolk.
    J Agric Food Chem 2010, 58, 7453-7. [PubMed] [Full Text]
  5. Shimizu Y, Nakamura A, Kishimura H, Hara A, Watanabe K, Saeki H:
    Major allergen and its IgE cross-reactivity among salmonid fish roe allergy.
    J Agric Food Chem 2009, 57, 2314-9. [PubMed] [Full Text]
  6. Blank S, Seismann H, McIntyre M, Ollert M, Wolf S, Bantleon FI, Spillner E:
    Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v 6) of Apis mellifera and Vespula vulgaris venom.
    PLoS One 2013, 8, e62009. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00094 von Willebrand factor type D domain -
PF01347 Lipoprotein amino terminal region CL0020 Tetratrico peptide repeat superfamily

Additional Pfam domains found in some family members:

Pfam domain Pfam clan
PF09172 Domain of unknown function (DUF1943) -
PF09175 Domain of unknown function (DUF1944) -

Links to Wikipedia


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