AF095: Melittin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Melittin is the principal protein component of the venom of the honeybee, Apis mellifera. It inhibits protein kinase C, Ca2+-calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase and is a cell membrane lytic factor [1]. Melittin is a small peptide with no disulphide bridge.

Allergens from this family

Melittin (Api m 4) is a minor honeybee venom allergen [2].



  1. Dempsey CE:
    The actions of melittin on membranes.
    Biochim Biophys Acta 1990, 1031, 143-61. [PubMed]
  2. Hoffman DR:
    Hymenoptera venom allergens.
    Clin Rev Allergy Immunol 2006, 30, 109-28. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01372 Melittin -

Links to Wikipedia


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