AF097: Collagen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Collagens are extracellular structural proteins involved in formation of connective tissue structure. The sequence consists predominantly or repeats of G-X-Y and the polypeptide chains form a triple helix. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure.

Allergens from this family

Bovine gelatin present in vaccines was shown to cause allergic reactions [1].



  1. Sakaguchi M, Hori H, Hattori S, Irie S, Imai A, Yanagida M, Miyazawa H, Toda M, Inouye S:
    IgE reactivity to alpha1 and alpha2 chains of bovine type 1 collagen in children with bovine gelatin allergy.
    J Allergy Clin Immunol 1999, 104, 695-9. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01391 Collagen triple helix repeat (20 copies) -
PF01410 Fibrillar collagen C-terminal domain CL0422 Fibrinogen C-terminal domain-like

Links to Wikipedia


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