AF098: Pheromone and odorant binding protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is thought to be greatly enhanced via odorant binding proteins which exist in the extracellular fluid surrounding the odorant receptors [1]. This family is composed of pheromone binding proteins (PBP) and general odorant binding proteins (GOBP) from insects.

Allergens from this family

Aed a 2 is a salivary allergen from the yellow-fever mosquito Aedes aegypti [2]. Homologous allergens were also identified in other mosquito species.



  1. Pelosi P:
    Odorant-binding proteins: structural aspects.
    Ann N Y Acad Sci 1998, 855, 281-93. [PubMed]
  2. Peng Z, Xu W, Lam H, Cheng L, James AA, Simons FE:
    A new recombinant mosquito salivary allergen, rAed a 2: allergenicity, clinical relevance, and cross-reactivity.
    Allergy 2006, 61, 485-90. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01395 PBP/GOBP family -

Links to Wikipedia


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