AF102: Group 5/6 grass pollen allergen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains pollen-specific proteins of about 30 kDa in size and unknown biological function, which were found only in grass species from the subfamily Pooideae [1]. A ribonuclease activity was reported for Phl p 5 from timothy grass [2].

Allergens from this family

Group 5 grass pollen allergens are major allergens, which elicit IgE responses in 65% to 85% of grass pollen-allergic patients [1]. Basic members of this family were originally termed group 9. Group 6 grass pollen allergens are major allergens of about 13 kDa, which are similar and cross-reactive to the C-terminal domain of group 5 allergens, but lack their N-terminal domain.



  1. Andersson K, Lidholm J:
    Characteristics and immunobiology of grass pollen allergens.
    Int Arch Allergy Immunol 2003, 130, 87-107. [PubMed] [Full Text]
  2. Bufe A, Schramm G, Keown MB, Schlaak M, Becker WM:
    Major allergen Phl p Vb in timothy grass is a novel pollen RNase.
    FEBS Lett 1995, 363, 6-12. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01620 Ribonuclease (pollen allergen) -


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