AF103: Hyaluronidase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Hyaluronidases (glycoside hydrolase family 56) are enzymes that degrade hyaluronic acid. They are found exclusively in animals. The human genome contains six genes from this family including PH-20, a membrane protein of mammalian sperm involved in sperm-egg adhesion [1]. Moreover, Hyaluronidases are components of venoms from various groups of animals [2].

Allergens from this family

Hyaluronidases are the group 2 allergens of bee and vespid venoms. They are glycoproteins that contain IgE binding N-glycans [3].



  1. Gmachl M, Kreil G:
    Bee venom hyaluronidase is homologous to a membrane protein of mammalian sperm.
    Proc Natl Acad Sci U S A 1993, 90, 3569-73. [PubMed]
  2. Fry BG, Roelants K, Champagne DE, Scheib H, Tyndall JD, King GF, Nevalainen TJ, Norman JA, Lewis RJ, Norton RS, Renjifo C, de la Vega RC:
    The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms.
    Annu Rev Genomics Hum Genet 2009, 10, 483-511. [PubMed] [Full Text]
  3. Kolarich D, Leonard R, Hemmer W, Altmann F:
    The N-glycans of yellow jacket venom hyaluronidases and the protein sequence of its major isoform in Vespula vulgaris.
    FEBS J 2005, 272, 5182-90. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01630 Hyaluronidase CL0058 Tim barrel glycosyl hydrolase superfamily

Links to Wikipedia


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