AF104: Patatin family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family consists of various glycoproteins from plants. Patatin accounts for up to 40% of total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids [1]. Members of this family have also been found in vertebrates.

Allergens from this family

Patatin is a major potato allergen. Its homology and cross-reactivity to the major Hevea brasiliensis latex allergen Hev b 7 explains the observation of potatoes being one of the plant foods involved in the latex-fruit syndrome [2].



  1. Shewry PR:
    Tuber storage proteins.
    Ann Bot 2003, 91, 755-69. [PubMed] [Full Text]
  2. Seppala U, Palosuo T, Seppala U, Kalkkinen N, Ylitalo L, Reunala T, Turjanmaa K, Reunala T:
    IgE reactivity to patatin-like latex allergen, Hev b 7, and to patatin of potato tuber, Sol t 1, in adults and children allergic to natural rubber latex.
    Allergy 2000, 55, 266-73. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01734 Patatin-like phospholipase CL0323 Patatin/FabD/lysophospholipase-like superfamily

Links to Wikipedia


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