AF107: NAC domain

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Nascent polypeptide-associated complex (NAC) is among the first ribosome-associated entities to bind the nascent polypeptide after peptide bond formation [1].

Allergens from this family

Human α-NAC was identified as an autoallergen [2].



  1. Rospert S, Dubaquie Y, Gautschi M:
    Nascent-polypeptide-associated complex.
    Cell Mol Life Sci 2002, 59, 1632-9. [PubMed]
  2. Mossabeb R, Seiberler S, Mittermann I, Reininger R, Spitzauer S, Natter S, Verdino P, Keller W, Kraft D, Valenta R:
    Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.
    J Invest Dermatol 2002, 119, 820-9. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01849 NAC domain -

Links to Wikipedia


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