AF109: Fungalysin metalloprotease

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Fungalysin is produced by Aspergillus and other fungi. It aids in degradation of the host's extracellular matrix proteins upon infection [1].

Allergens from this family

Asp f 5 is a major allergen from Aspergillus fumigatus [2].



  1. Fernandez D, Russi S, Vendrell J, Monod M, Pallares I:
    A functional and structural study of the major metalloprotease secreted by the pathogenic fungus Aspergillus fumigatus.
    Acta Crystallogr D Biol Crystallogr 2013, 69, 1946-57. [PubMed] [Full Text]
  2. Crameri R:
    Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications.
    Int Arch Allergy Immunol 1998, 115, 99-114. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02128 Fungalysin metallopeptidase (M36) CL0126 Peptidase clan MA
PF07504 Fungalysin/Thermolysin Propeptide Motif -


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