AF110: Nuclear transport factor 2

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Nuclear transport factor 2 (NTF2) is a homodimer of approximately 14 kDa subunits which stimulates efficient nuclear import of a cargo protein. NTF2 binds to both Ran-GDP and FxFG repeat-containing nucleoporins [1].

Allergens from this family

Fungal NTF2 was identified as cross-reactive allergen [2].



  1. Stewart M:
    Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2).
    Cell Struct Funct 2000, 25, 217-25. [PubMed]
  2. Weichel M, Schmid-Grendelmeier P, Fluckiger S, Breitenbach M, Blaser K, Crameri R:
    Nuclear transport factor 2 represents a novel cross-reactive fungal allergen.
    Allergy 2003, 58, 198-206. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02136 Nuclear transport factor 2 (NTF2) domain CL0051 NTF2-like superfamily

Links to Wikipedia


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