AF111: Group 2 mite allergen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The MD-2-related lipid recognition domain (ML domain) has an immunoglobulin-like beta-sandwich fold and is found in proteins from plants, animals and fungi. It has been implicated in lipid recognition, particularly in the recognition of pathogen-related products. A member of this family is MD-2, an extracellular protein that binds lipopolysaccharide and induces the innate immune response by binding to Toll-like receptor 4 [1].

Allergens from this family

Group 2 mite allergens are major and partially cross-reactive allergens identified in a large number of mite species [2]. Der p 2 from Dermatophagoides pteronyssinus was shown to mimic the biological function of MD-2, which may explain its allergenic activity [3].



  1. Visintin A, Iliev DB, Monks BG, Halmen KA, Golenbock DT:
    Immunobiology 2006, 211, 437-47. [PubMed] [Full Text]
  2. Thomas WR, Smith WA, Hales BJ, Mills KL, O'Brien RM:
    Characterization and immunobiology of house dust mite allergens.
    Int Arch Allergy Immunol 2002, 129, 1-18. [PubMed] [Full Text]
  3. Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, Madan R, Thorne PS, Wills-Karp M, Gioannini TL, Weiss JP, Karp CL:
    Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein.
    Nature 2009, 457, 585-8. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02221 ML domain CL0532 Lipid-binding Ig-like superfamily

Links to Wikipedia


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