The MD-2-related lipid recognition domain (ML domain) has an immunoglobulin-like beta-sandwich fold and is found in proteins from plants, animals and fungi. It has been implicated in lipid recognition, particularly in the recognition of pathogen-related products. A member of this family is MD-2, an extracellular protein that binds lipopolysaccharide and induces the innate immune response by binding to Toll-like receptor 4 [1].
Group 2 mite allergens are major and partially cross-reactive allergens identified in a large number of mite species [2]. Der p 2 from Dermatophagoides pteronyssinus was shown to mimic the biological function of MD-2, which may explain its allergenic activity [3].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF02221 | ML domain | CL0532 | Lipid-binding Ig-like superfamily |
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