AF120: Plant invertase/pectin methylesterase inhibitor

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family inhibit pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex [1]. They have been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension. They may also be involved in inhibiting microbial pathogen PMEs.

Allergens from this family

The major plane tree (Platanus acerifolia) pollen allergen, Pla a 1 [2], and the minor kiwi fruit allergen Act d 6 belong to this family.



  1. Giovane A, Servillo L, Balestrieri C, Raiola A, D'Avino R, Tamburrini M, Ciardiello MA, Camardella L:
    Pectin methylesterase inhibitor.
    Biochim Biophys Acta 2004, 1696, 245-52. [PubMed] [Full Text]
  2. Asturias JA, Ibarrola I, Eraso E, Arilla MC, Martinez A:
    The major Platanus acerifolia pollen allergen Pla a 1 has sequence homology to invertase inhibitors.
    Clin Exp Allergy 2003, 33, 978-85. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF04043 Plant invertase/pectin methylesterase inhibitor -


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