AF125: Rubber elongation factor family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This protein family consists of the highly related rubber elongation factor (REF), small rubber particle protein (SRPP) and stress-related protein (SRP). REF and SRPP are released from the rubber particle membrane into the cytosol during osmotic lysis of the sedimentable organelles (lutoids). The exact function of this family is unknown [1].

Allergens from this family

This family includes the two allergens Hev b 1 and Hev b 3 from the rubber tree Hevea brasiliensis. These proteins were the most important allergens for latex allergic children with spina bifida, before the incidence of latex allergy in this group of patients could be remarkably reduced due to strict avoidance of exposure to latex [2].



  1. Sookmark U, Pujade-Renaud V, Chrestin H, Lacote R, Naiyanetr C, Seguin M, Romruensukharom P, Narangajavana J:
    Characterization of polypeptides accumulated in the latex cytosol of rubber trees affected by the tapping panel dryness syndrome.
    Plant Cell Physiol 2002, 43, 1323-33. [PubMed]
  2. Wagner S, Breiteneder H:
    Hevea brasiliensis latex allergens: current panel and clinical relevance.
    Int Arch Allergy Immunol 2005, 136, 90-7. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF05755 Rubber elongation factor protein (REF) -

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .