AF127: Group 1 cockroach allergen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family consists of several insect specific proteins. Members of this family are commonly found in cockroaches, fruit flies and mosquitos. It has been suggested that the repeat sequences have evolved by duplication of an ancestral amino acid domain, which may have arisen from the mitochondrial energy transfer proteins [1].

Allergens from this family

Bla g 1 and Per a 1 are major, cross-reactive allergens from German and American cockroach, respectively [1].



  1. Pomes A, Melen E, Vailes LD, Retief JD, Arruda LK, Chapman MD:
    Novel allergen structures with tandem amino acid repeats derived from German and American cockroach.
    J Biol Chem 1998, 273, 30801-7. [PubMed]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF06757 Insect allergen related repeat, nitrile-specifier detoxification -


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