AF134: Uteroglobin

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Uteroglobin (or blastokinin) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, inhibiting phospholipase A2 activity, and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins. Ulteroglobin is a member of the secretoglobin family that also contains mammaglobin, lipophilin B, and the cat allergen Fel d 1 [1]. Members of this family form disulfide-linked homo- or heterodimers. The subunits adopt a helical fold composed of 4 helices.

Allergens from this family

Fel d 1 is the major cat dander allergen [2]. Another allergenic member of this family is the rabbit dander allergen Ory c 3 [3].



  1. Jackson BC, Thompson DC, Wright MW, McAndrews M, Bernard A, Nebert DW, Vasiliou V:
    Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily.
    Hum Genomics 2011, 5, 691-702. [PubMed]
  2. Liccardi G, D'Amato G, Russo M, Canonica GW, D'Amato L, De Martino M, Passalacqua G:
    Focus on cat allergen (Fel d 1): immunological and aerodynamic characteristics, modality of airway sensitization and avoidance strategies.
    Int Arch Allergy Immunol 2003, 132, 1-12. [PubMed] [Full Text]
  3. Hilger C, Kler S, Arumugam K, Revets D, Muller CP, Charpentier C, Lehners C, Morisset M, Hentges F:
    Identification and isolation of a Fel d 1-like molecule as a major rabbit allergen.
    J Allergy Clin Immunol 2014, 133, 759-66. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01099 Uteroglobin family CL0370 Uteroglobin-like superfamily
PF09252 Allergen Fel d I-B chain CL0370 Uteroglobin-like superfamily

Links to Wikipedia


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