Uteroglobin (or blastokinin) is a mammalian steroid-inducible secreted protein originally isolated from the uterus of rabbits during early pregnancy. The mucosal epithelia of several organs that communicate with the external environment express uteroglobin. Uteroglobin may be a multi-functional protein with anti-inflammatory/immunomodulatory properties, inhibiting phospholipase A2 activity, and binding to (and possibly sequestering) several hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids and prostaglandins. Ulteroglobin is a member of the secretoglobin family that also contains mammaglobin, lipophilin B, and the cat allergen Fel d 1 [1]. Members of this family form disulfide-linked homo- or heterodimers. The subunits adopt a helical fold composed of 4 helices.
Fel d 1 is the major cat dander allergen [2]. Another allergenic member of this family is the rabbit dander allergen Ory c 3 [3].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF01099 | Uteroglobin family | CL0370 | Uteroglobin-like superfamily |
| PF09252 | Allergen Fel d I-B chain | CL0370 | Uteroglobin-like superfamily |
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