AF135: Ole e 6 family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family fold into a structure consisting of two nearly anti-parallel α-helices that are connected by a short loop and followed by a long, unstructured C-terminal tail. They contain 3 disulfide bonds. Their biological function is unknown.

Allergens from this family

One member of this family, the pollen protein Ole e 6 from olive tree (Olea europaea), exhibits allergenic activity with a high prevalence among olive pollen-allergic individuals [1, 2].



  1. Trevino MA, Garcia-Mayoral MF, Barral P, Villalba M, Santoro J, Rico M, Rodriguez R, Bruix M:
    NMR solution structure of Ole e 6, a major allergen from olive tree pollen.
    J Biol Chem 2004, 279, 39035-41. [PubMed] [Full Text]
  2. Barral P, Tejera ML, Trevino MA, Batanero E, Villalba M, Bruix M, Rodriguez R:
    Recombinant expression of Ole e 6, a Cys-enriched pollen allergen, in Pichia pastoris yeast: detection of partial oxidation of methionine by NMR.
    Protein Expr Purif 2004, 37, 336-43. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF09253 Pollen allergen ole e 6 -


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