The translationally controlled tumour protein (TCTP) is a highly conserved protein that is widely expressed in all eukaryotic organisms . Mammalian TCTP (also termed P23 or histamine releasing factor) has been found to be preferentially synthesized in cells during the early growth phase of some types of tumour but is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis.
TCTP from the mould Cladosporium herbarum was shown to be a major allergen cross-reactive with its human homologue .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00838||Translationally controlled tumour protein||CL0080||Beta-tent fold|
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