AF136: Translationally controlled tumour protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The translationally controlled tumour protein (TCTP) is a highly conserved protein that is widely expressed in all eukaryotic organisms [1]. Mammalian TCTP (also termed P23 or histamine releasing factor) has been found to be preferentially synthesized in cells during the early growth phase of some types of tumour but is also expressed in normal cells. It was first identified as a histamine-releasing factor, acting in IgE-dependent allergic reactions. In addition, TCTP has been shown to bind to tubulin in the cytoskeleton, has a high affinity for calcium, is the binding target for the antimalarial compound artemisinin, and is induced in vitamin D-dependent apoptosis.

Allergens from this family

TCTP from the mould Cladosporium herbarum was shown to be a major allergen cross-reactive with its human homologue [2].



  1. Bommer UA, Thiele BJ:
    The translationally controlled tumour protein (TCTP).
    Int J Biochem Cell Biol 2004, 36, 379-85. [PubMed]
  2. Rid R, Simon-Nobbe B, Langdon J, Holler C, Wally V, Poll V, Ebner C, Hemmer W, Hawranek T, Lang R, Richter K, MacDonald S, Rinnerthaler M, Laun P, Mari A, Breitenbach M:
    Cladosporium herbarum translationally controlled tumor protein (TCTP) is an IgE-binding antigen and is associated with disease severity.
    Mol Immunol 2008, 45, 406-18. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00838 Translationally controlled tumour protein CL0080 Beta-tent fold

Links to Wikipedia


If you have updates or corrections for this entry, please contact the site administrator: .