AF137: SXP/RAL-2 family
Members of this family were found in nematodes. Their function is unknown. Ani s 5 from the fish parasite Anisakis simplex folds into a calmodulin-likes α-helical structure. However, the protein binds Mg2+ but not Ca2+ .
Allergens from this family
Ani s 5, Ani s 8 and Ani s 9 from the fish parasite Anisakis simplex belong to this family [2, 3, 4].
Relationships between IgE/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP/RAL-2 protein family.
PLoS Negl Trop Dis 2014, 8, e2735. [PubMed] [Full Text]
Molecular cloning and expression of two new allergens from Anisakis simplex.
Parasitol Res 2007, 100, 1233-41. [PubMed] [Full Text]
Purification and cDNA cloning of a new heat-stable allergen from Anisakis simplex.
Mol Biochem Parasitol 2007, 155, 138-45. [PubMed] [Full Text]
Cloning and expression of Ani s 9, a new Anisakis simplex allergen.
Mol Biochem Parasitol 2008, 159, 92-7. [PubMed] [Full Text]
Links to Pfam
Family-defining Pfam domains (at least one of these domains is present in each family member):
Domain of unknown function DUF148
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