AF137: SXP/RAL-2 family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Members of this family were found in nematodes. Their function is unknown. Ani s 5 from the fish parasite Anisakis simplex folds into a calmodulin-likes α-helical structure. However, the protein binds Mg2+ but not Ca2+ [1].

Allergens from this family

Ani s 5, Ani s 8 and Ani s 9 from the fish parasite Anisakis simplex belong to this family [2, 3, 4].



  1. Garcia-Mayoral MF, Trevino MA, Perez-Pinar T, Caballero ML, Knaute T, Umpierrez A, Bruix M, Rodriguez-Perez R:
    Relationships between IgE/IgG4 epitopes, structure and function in Anisakis simplex Ani s 5, a member of the SXP/RAL-2 protein family.
    PLoS Negl Trop Dis 2014, 8, e2735. [PubMed] [Full Text]
  2. Kobayashi Y, Ishizaki S, Shimakura K, Nagashima Y, Shiomi K:
    Molecular cloning and expression of two new allergens from Anisakis simplex.
    Parasitol Res 2007, 100, 1233-41. [PubMed] [Full Text]
  3. Kobayashi Y, Shimakura K, Ishizaki S, Nagashima Y, Shiomi K:
    Purification and cDNA cloning of a new heat-stable allergen from Anisakis simplex.
    Mol Biochem Parasitol 2007, 155, 138-45. [PubMed] [Full Text]
  4. Rodriguez-Perez R, Moneo I, Rodriguez-Mahillo A, Caballero ML:
    Cloning and expression of Ani s 9, a new Anisakis simplex allergen.
    Mol Biochem Parasitol 2008, 159, 92-7. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF02520 Domain of unknown function DUF148 -


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