AF140: Carboxylesterase

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Carboxylesterases are enzymes that hydrolyse carboxyl esters. Examples are acetylcholinesterases and lipases. Carboxylesterases were classified into three categories (A, B and C) on the basis of different patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates that the majority are evolutionary related [1]. The active center of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This family belongs to the superfamily of proteins with the α/β hydrolase fold.

Allergens from this family

The 70 kDa bee venom allergen Api m 8 belongs to this family.



  1. Cygler M, Schrag JD, Sussman JL, Harel M, Silman I, Gentry MK, Doctor BP:
    Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins.
    Protein Sci 1993, 2, 366-82. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00135 Carboxylesterase family CL0028 Alpha/Beta hydrolase fold

Links to Wikipedia


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