WD-40 repeats (also known as WD or beta-transducin repeats) are short motifs (about 40 amino acids), often terminating by a Trp-Asp (WD) dipeptide. WD-containing proteins have 4 to 16 repeating units and are thought to form a beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes with a variety of functions ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis. The underlying common function of all WD40-repeat proteins is coordinating multi-protein complex assemblies, where the repeating units serve as a rigid scaffold for protein interactions [1].
For t 2 from the biting midge Forcipomyia taiwana, a eukaryotic translation initiation factor 3 subunit, belongs to this family [2].
Family-defining Pfam domains (at least one of these domains is present in each family member):
| Pfam domain | Pfam clan | ||
| PF00400 | WD domain, G-beta repeat | CL0186 | Beta propeller clan |
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