AF142: WD-40 repeat

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

WD-40 repeats (also known as WD or beta-transducin repeats) are short motifs (about 40 amino acids), often terminating by a Trp-Asp (WD) dipeptide. WD-containing proteins have 4 to 16 repeating units and are thought to form a beta-propeller structure. WD-repeat proteins are a large family found in all eukaryotes with a variety of functions ranging from signal transduction and transcription regulation to cell cycle control, autophagy and apoptosis. The underlying common function of all WD40-repeat proteins is coordinating multi-protein complex assemblies, where the repeating units serve as a rigid scaffold for protein interactions [1].

Allergens from this family

For t 2 from the biting midge Forcipomyia taiwana, a eukaryotic translation initiation factor 3 subunit, belongs to this family [2].



  1. Stirnimann CU, Petsalaki E, Russell RB, Muller CW:
    WD40 proteins propel cellular networks.
    Trends Biochem Sci 2010, 35, 565-74. [PubMed] [Full Text]
  2. Chen YH, Hwang GY, Chen PC, Tu WC, Lee MF:
    Molecular cloning and immunologic characterization of for t 2: a major allergen from the biting midge Forcipomyia taiwana.
    Allergy 2011, 66, 703-5. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00400 WD domain, G-beta repeat CL0186 Beta propeller clan

Links to Wikipedia


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