Leucine Rich Repeats (LRR) are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. LRR domains are composed of beta-alpha units that form curved horseshoe structures with a parallel beta sheet on the concave side and mostly helical elements on the convex side. LRR domains are often flanked by cysteine rich domains [1, 2].
An LRR-containing protein from wheat was found by screening a phage display wheat cDNA library with wheat allergic patients' IgE .
Family-defining Pfam domains (at least one of these domains is present in each family member):
|Pfam domain||Pfam clan|
|PF00560||Leucine Rich Repeat||CL0022||Leucine Rich Repeat|
|PF08263||Leucine rich repeat N-terminal domain||-|
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