AF143: Leucine-rich repeat

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

Leucine Rich Repeats (LRR) are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. LRR domains are composed of beta-alpha units that form curved horseshoe structures with a parallel beta sheet on the concave side and mostly helical elements on the convex side. LRR domains are often flanked by cysteine rich domains [1, 2].

Allergens from this family

An LRR-containing protein from wheat was found by screening a phage display wheat cDNA library with wheat allergic patients' IgE [3].



  1. Enkhbayar P, Kamiya M, Osaki M, Matsumoto T, Matsushima N:
    Structural principles of leucine-rich repeat (LRR) proteins.
    Proteins 2004, 54, 394-403. [PubMed] [Full Text]
  2. Kobe B, Kajava AV:
    The leucine-rich repeat as a protein recognition motif.
    Curr Opin Struct Biol 2001, 11, 725-32. [PubMed]
  3. Weichel M, Vergoossen NJ, Bonomi S, Scibilia J, Ortolani C, Ballmer-Weber BK, Pastorello EA, Crameri R:
    Screening the allergenic repertoires of wheat and maize with sera from double-blind, placebo-controlled food challenge positive patients.
    Allergy 2006, 61, 128-35. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00560 Leucine Rich Repeat CL0022 Leucine Rich Repeat
PF08263 Leucine rich repeat N-terminal domain -

Links to Wikipedia


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