AF154: Major royal jelly protein

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

The major royal jelly proteins comprise 12.5% of the mass and 82-90% of the protein content of honeybee royal jelly [1]. Royal jelly is a substance secreted by the cephalic glands of nurse bees and it is used to trigger development of a queen bee from a bee larva. The biological function of the MRJPs is unknown, but they are believed to play a major role in nutrition due to their high content of essential amino acids. In addition, the protein is cleaved into peptides, the jelleins, with antibacterial and antifungal activities [2].

Allergens from this family

Two royal jelly proteins, MRJP1 and MRJP2, were identified as major allergens involved in food allergic reactions to royal jelly [3]. Two members of this family, MRJP8 and MRJP9, were found in bee venom and characterised as minor allergen, Api m 11 [4].



  1. Schmitzova J, Klaudiny J, Albert S, Schroder W, Schreckengost W, Hanes J, Judova J, Simuth J:
    A family of major royal jelly proteins of the honeybee Apis mellifera L.
    Cell Mol Life Sci 1998, 54, 1020-30. [PubMed]
  2. Fontana R, Mendes MA, de Souza BM, Konno K, Cesar LM, Malaspina O, Palma MS:
    Jelleines: a family of antimicrobial peptides from the Royal Jelly of honeybees (Apis mellifera).
    Peptides 2004, 25, 919-28. [PubMed] [Full Text]
  3. Rosmilah M, Shahnaz M, Patel G, Lock J, Rahman D, Masita A, Noormalin A:
    Characterization of major allergens of royal jelly Apis mellifera.
    Trop Biomed 2008, 25, 243-51. [PubMed]
  4. Blank S, Bantleon FI, McIntyre M, Ollert M, Spillner E:
    The major royal jelly proteins 8 and 9 (Api m 11) are glycosylated components of Apis mellifera venom with allergenic potential beyond carbohydrate-based reactivity.
    Clin Exp Allergy 2012, 42, 976-85. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF03022 Major royal jelly protein CL0186 Beta propeller clan

Links to Wikipedia


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