AF155: GILT family

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains proteins homologous to the two characterised human gamma-interferon-inducible lysosomal thiol reductases (GILT) [1].

Allergens from this family

A wheat allergen, Tri a 27 (formerly Tri a Bd 27K) belongs to this family. The glycosylated natural protein, but not the recombinant one, bound human IgE [2].



  1. Phan UT, Maric M, Dick TP, Cresswell P:
    Multiple species express thiol oxidoreductases related to GILT.
    Immunogenetics 2001, 53, 342-6. [PubMed]
  2. Kimoto M, Suzuki M, Komiyama N, Kunimoto A, Yamashita H, Hiemori M, Takahashi K, Tsuji H:
    Isolation and molecular cloning of a major wheat allergen, Tri a Bd 27K.
    Biosci Biotechnol Biochem 2009, 73, 85-92. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT) CL0172 Thioredoxin-like


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