AF156: Group 5/21 mite allergen

List allergens from this family:

Routes of exposure:
Include only IUIS approved allergens.

Biochemical properties

This family contains alpha-helical proteins of unknown function found exclusively in mites [1].

Allergens from this family

Two groups of mite allergens belong to this family. Group 5 allergens are major allergens, especially important in the tropical species Blomia tropicalis (Blo t 5). Cross-reactivity between group 5 allergens from different mite species appears to be low [2]. Group 21 allergens are major allergens that showed low to moderate cross-reactivity to group 5 allergens [3].



  1. Chan SL, Ong TC, Gao YF, Tiong YS, Wang de Y, Chew FT, Mok YK:
    Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen.
    J Immunol 2008, 181, 2586-96. [PubMed]
  2. Kuo IC, Cheong N, Trakultivakorn M, Lee BW, Chua KY:
    An extensive study of human IgE cross-reactivity of Blo t 5 and Der p 5.
    J Allergy Clin Immunol 2003, 111, 603-9. [PubMed]
  3. Gao YF, Wang de Y, Ong TC, Tay SL, Yap KH, Chew FT:
    Identification and characterization of a novel allergen from Blomia tropicalis: Blo t 21.
    J Allergy Clin Immunol 2007, 120, 105-12. [PubMed] [Full Text]


Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF11642 Mite allergen Blo t 5 -


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